Mutations in the amino terminus of the cystic fibrosis transmembrane conductance regulator enhance endocytosis
A Jurkuvenaite, K Varga, K Nowotarski, KL Kirk… - Journal of Biological …, 2006 - ASBMB
Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator (CFTR) is
mediated by a tyrosine-based internalization signal in the CFTR carboxyl-terminal tail 1424
YDSI 1427. In the present studies, two naturally occurring cystic fibrosis mutations in the
amino terminus of CFTR, R31C, and R31L were examined. To determine the defect that
these mutations cause, the Arg-31 mutants were expressed in COS-7 cells and their
biogenesis and trafficking to the cell surface tested in metabolic pulse-chase and surface …
mediated by a tyrosine-based internalization signal in the CFTR carboxyl-terminal tail 1424
YDSI 1427. In the present studies, two naturally occurring cystic fibrosis mutations in the
amino terminus of CFTR, R31C, and R31L were examined. To determine the defect that
these mutations cause, the Arg-31 mutants were expressed in COS-7 cells and their
biogenesis and trafficking to the cell surface tested in metabolic pulse-chase and surface …
