Animal models of external traumatic wound infections
Virulence, 2011•Taylor & Francis
Background: Despite advances in traumatic wound care and management, infections
remain a leading cause of mortality, morbidity, and economic disruption in millions of wound
patients around the world. Animal models have become standard tools for studying a wide
array of external traumatic wound infections and testing new antimicrobial strategies.
Methods: This review covers experimental infections in animal models of surgical wounds,
skin abrasions, burns, lacerations, excisional wounds, and open fractures. Results: Animal …
remain a leading cause of mortality, morbidity, and economic disruption in millions of wound
patients around the world. Animal models have become standard tools for studying a wide
array of external traumatic wound infections and testing new antimicrobial strategies.
Methods: This review covers experimental infections in animal models of surgical wounds,
skin abrasions, burns, lacerations, excisional wounds, and open fractures. Results: Animal …
Background: Despite advances in traumatic wound care and management, infections remain a leading cause of mortality, morbidity, and economic disruption in millions of wound patients around the world. Animal models have become standard tools for studying a wide array of external traumatic wound infections and testing new antimicrobial strategies.
Methods: This review covers experimental infections in animal models of surgical wounds, skin abrasions, burns, lacerations, excisional wounds, and open fractures.
Results: Animal models of external traumatic wound infections reported by different investigators vary in animal species used, microorganism strains, the number of microorganisms applied, the size of the wounds, and, for burn infections, the length of time the heated object or liquid is in contact with the skin.
Conclusions: As antibiotic resistance continues to increase, more new antimicrobial approaches are urgently needed. These should be tested using standard protocols for infections in external traumatic wounds in animal models.
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