[HTML][HTML] Leishmania donovani exploits myeloid cell leukemia 1 (MCL-1) protein to prevent mitochondria-dependent host cell apoptosis
J Giri, S Srivastav, M Basu, S Palit, P Gupta… - Journal of Biological …, 2016 - ASBMB
Apoptosis is one of the mechanisms used by host cells to remove unwanted intracellular
organisms, and often found to be subverted by pathogens through use of host anti-apoptotic
proteins. In the present study, with the help of in vitro and in vivo approaches, we
documented that the macrophage anti-apoptotic protein myeloid cell leukemia 1 (MCL-1) is
exploited by the intra-macrophage parasite Leishmania donovani to protect their" home"
from actinomycin D-induced mitochondria-dependent apoptosis. Among all the anti …
organisms, and often found to be subverted by pathogens through use of host anti-apoptotic
proteins. In the present study, with the help of in vitro and in vivo approaches, we
documented that the macrophage anti-apoptotic protein myeloid cell leukemia 1 (MCL-1) is
exploited by the intra-macrophage parasite Leishmania donovani to protect their" home"
from actinomycin D-induced mitochondria-dependent apoptosis. Among all the anti …
