Background Large plexiform neurofibromas can cause significant morbidity, functional
impairment, and may be even life threatening. They most commonly arise in association with
major nerve trunks and follow the distribution of the involved peripheral nerves, and can be
subject to transformation into malignant peripheral nerve sheet tumors. They produce large
infiltrative masses, which can involve major portions of the trunk or extremities. The main
goal of this project is to analyze our surgical experience with plexiform neurofibromas …