Peripheral nerve injury (PNI) is common and, unlike damage to the central nervous system
injured nerves can effectively regenerate depending on the location and severity of injury.
Peripheral myelinating glia, Schwann cells (SCs), interact with various cells in and around
the injury site and are important for debris elimination, repair, and nerve regeneration.
Following PNI, Wallerian degeneration of the distal stump is rapidly initiated by
degeneration of damaged axons followed by morphologic changes in SCs and the …