LRRK2 signaling in neurodegeneration: two decades of progress
L Iannotta, E Greggio - Essays in Biochemistry, 2021 - portlandpress.com
L Iannotta, E Greggio
Essays in Biochemistry, 2021•portlandpress.comLeucine-rich repeat kinase 2 (LRRK2) is a complex GTPase/kinase orchestrating
cytoskeletal dynamics and multiple steps of the endolysosomal pathway through interaction
with a host of partners and phosphorylation of a subset of Rab GTPases. Mutations in
LRRK2 cause late-onset Parkinson's disease (PD) and common variants in the locus
containing LRRK2 have been associated with sporadic PD, progressive supranuclear palsy
as well as a number of inflammatory diseases. This review encompasses the major …
cytoskeletal dynamics and multiple steps of the endolysosomal pathway through interaction
with a host of partners and phosphorylation of a subset of Rab GTPases. Mutations in
LRRK2 cause late-onset Parkinson's disease (PD) and common variants in the locus
containing LRRK2 have been associated with sporadic PD, progressive supranuclear palsy
as well as a number of inflammatory diseases. This review encompasses the major …
Abstract
Leucine-rich repeat kinase 2 (LRRK2) is a complex GTPase/kinase orchestrating cytoskeletal dynamics and multiple steps of the endolysosomal pathway through interaction with a host of partners and phosphorylation of a subset of Rab GTPases. Mutations in LRRK2 cause late-onset Parkinson's disease (PD) and common variants in the locus containing LRRK2 have been associated with sporadic PD, progressive supranuclear palsy as well as a number of inflammatory diseases. This review encompasses the major discoveries in the field of LRRK2 pathobiology, from the initial gene cloning to the latest progress in LRRK2 inhibition as a promising therapeutic approach to fight neurodegeneration.
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