Exocytosis operates through two distinct modes. Full-fusion leads to rapid expulsion of the
entire content of a vesicle; kiss-and-run leads to slow and partial expulsion. These two
modes have important biological consequences for endocrine regulation and synaptic
transmission. Amperometry recordings of catecholamine release from chromaffin cells
reveal single-vesicle fusion events corresponding to both of these modes, but classification
is often difficult. This study introduces a new method of analyzing amperometry data to …