Expression and Functional Role of Syntaxin 1/HPC-1 in Pancreatic β Cells: SYNTAXIN 1A, BUT NOT 1B, PLAYS A NEGATIVE ROLE IN REGULATORY INSULIN …
S Nagamatsu, T Fujiwara, Y Nakamichi… - Journal of Biological …, 1996 - ASBMB
Syntaxin 1/HPC-1 is an integral membrane protein, which is thought to be implicated in the
regulation of synaptic neurotransmitter release. We investigated syntaxin 1 expression in
pancreatic β cells and the functional role of syntaxin 1 in the insulin release mechanism.
Expression of syntaxin 1A, but not 1B, was detected in mouse isolated islets by the reverse
transcriptase-polymerase chain reaction procedure. An immunoprecipitation study of
metabolically labeled islets with an anti-rat syntaxin 1/HPC-1 antibody demonstrated …
regulation of synaptic neurotransmitter release. We investigated syntaxin 1 expression in
pancreatic β cells and the functional role of syntaxin 1 in the insulin release mechanism.
Expression of syntaxin 1A, but not 1B, was detected in mouse isolated islets by the reverse
transcriptase-polymerase chain reaction procedure. An immunoprecipitation study of
metabolically labeled islets with an anti-rat syntaxin 1/HPC-1 antibody demonstrated …
