Functional significance of the activation-associated receptors CD25 and CD69 on human NK-cells and NK-like T-cells
J Clausen, B Vergeiner, M Enk, AL Petzer, G Gastl… - Immunobiology, 2003 - Elsevier
The application of autologous ex-vivo expanded cytotoxic lymphocytes to cancer patients
may help to control minimal residual disease. However, the number of effector cells and the
resulting antitumoral activity that can be generated in vitro are remarkably variable. Thus, we
separately assessed the proliferative and cytotoxic potential of CD56+ CD3− natural killer
(NK) and CD56+ CD3+ T-cells in relation to their expression of CD25, CD69, and CD16 in
vitro. Two-week lymphocyte cultures from peripheral blood (n= 51) and from G-CSF …
may help to control minimal residual disease. However, the number of effector cells and the
resulting antitumoral activity that can be generated in vitro are remarkably variable. Thus, we
separately assessed the proliferative and cytotoxic potential of CD56+ CD3− natural killer
(NK) and CD56+ CD3+ T-cells in relation to their expression of CD25, CD69, and CD16 in
vitro. Two-week lymphocyte cultures from peripheral blood (n= 51) and from G-CSF …