Sex-and age-related differences of metabolic parameters in impaired glucose metabolism and type 2 diabetes compared to normal glucose tolerance
A Tura, G Pacini, E Moro, J Vrbíková… - Diabetes Research and …, 2018 - Elsevier
A Tura, G Pacini, E Moro, J Vrbíková, B Bendlová, A Kautzky-Willer
Diabetes Research and Clinical Practice, 2018•ElsevierAims This study analysed potential sex differences in glucose metabolism of European
subjects with different degrees of glucose tolerance impairment. Methods Subjects with
impaired glucose metabolism, IGM (n= 735), or type 2 diabetes, T2DM (n= 415), were
compared to subjects with normal glucose tolerance, NGT (n= 422), with similar BMI. For
both males (M) and females (F), 50 years threshold was used for estimation of menopausal/
andropausal state. Subjects underwent 75-g OGTT for measurements of insulin sensitivity …
subjects with different degrees of glucose tolerance impairment. Methods Subjects with
impaired glucose metabolism, IGM (n= 735), or type 2 diabetes, T2DM (n= 415), were
compared to subjects with normal glucose tolerance, NGT (n= 422), with similar BMI. For
both males (M) and females (F), 50 years threshold was used for estimation of menopausal/
andropausal state. Subjects underwent 75-g OGTT for measurements of insulin sensitivity …
Aims
This study analysed potential sex differences in glucose metabolism of European subjects with different degrees of glucose tolerance impairment.
Methods
Subjects with impaired glucose metabolism, IGM (n = 735), or type 2 diabetes, T2DM (n = 415), were compared to subjects with normal glucose tolerance, NGT (n = 422), with similar BMI. For both males (M) and females (F), 50 years threshold was used for estimation of menopausal/andropausal state. Subjects underwent 75-g OGTT for measurements of insulin sensitivity (OGIS), beta-cell function (insulinogenic index, IGIC), and overall metabolic condition, disposition index (DI).
Results
In IGM, OGIS did not change with age in both sexes, whereas marked reduction of IGIC was seen in F (p = 0.0003). In T2DM, again OGIS did not change with age, but M ≥ 50 yrs had reduced IGIC and DI (p < 0.002) compared to M < 50 yrs.
Conclusions
IGM did not reveal relevant changes of insulin resistance with age, but early phase insulin release deteriorated, with higher change in women. T2DM men featured age-related deterioration of glucose metabolism. In women, sex advantage seen in NGT vanished in T2DM, since glucose metabolism was overall not different than in men, both young and elderly.
Elsevier